Download e-book for iPad: Aging and Cancer by Frederick F. Holmes M.D. (auth.)

By Frederick F. Holmes M.D. (auth.)

ISBN-10: 3642821014

ISBN-13: 9783642821011

ISBN-10: 3642821030

ISBN-13: 9783642821035

The lifetime of a person is finite, and all people age (see Fries 1980). it truly is tricky to split the results of illness on organs and tissues from these anticipated of getting older. this can be rather precise for vascular and degenerative procedures, for which there are not any transparent limitations among getting older and affliction. Morbidity and mortality from center ailment and stroke are most likely due either to affliction and to alterations of getting older. For melanoma, the second one top reason behind demise in the United States, the placement is sort of diverse; melanoma is obviously a illness and isn't a metamorphosis anticipated with getting older. melanoma prevalence raises nearly logarithmically after age forty. within the usa approximately one-half of all instances of melanoma are clinically determined after age sixty five, even if these over sixty five contain lower than one-eighth of the inhabitants. therefore, melanoma is particularly a lot a disorder of the aged. There are no less than purposes for this: first, the lengthy publicity to cancer-inducing brokers, and moment, the waning strength of immune defenses opposed to cancer.

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N Engl J Med 303: 485-488 Weiss NS (1978) Noncontraceptive estrogens and abnormalities of endometrial proliferation. Ann Intern Med 88: 410-412 Weiss NS, Szekely DR, Austin DF (1976) Increasing incidence of endometrial cancer in the United States. N Engl J Med 294: 1259-1262 Weiss NS, Szekely DR, English DR, Schweid AI (1979) Endometrial cancer in relation to patterns of menopausal estrogen use. JAMA 242: 261-264 Yoonessi M, Anderson DG, Morley GW (1979) Endometrial carcinoma: causes of death and sites of treatment failure.

Surgery and radiotherapy, singly or in combination, are usually curative in locally confined disease. Nearly 50% of treatment failures are local, so one can make a very good case for hysterectomy whether or not radiation therapy is used. For advanced and recurrent disease chemotherapy has proved of little use. Local Just about 75% of all endometrial cancer is presently diagnosed while confined to the uterus, as opposed to about 50% in the 1950-1969 period. This probably reflects earlier attention to postmenopausal vaginal bleeding and could also represent the increased incidence of this cancer in its most differentiated, and thus, least dangerous state, perhaps as the consequence of increased use of estrogens.

300 ~g ClO <0 ... 0 <~ =>11: ~~ 200 < w CI < II: W ~ 100 SO-54 55-59 60-64 65-69 70-74 AGE IN YEARS 75-79 80-84 85" Fig. 1. Incidence of ovarian cancer in USA 1973-1977 31 Regional women with advanced disease. Single drugs, usually an alkylating agent, and lately multi-agent treatment schemes have been surprisingly effective in some reported studies (Tobias and Griffiths 1976; Bagley et al. 1972; Young et al. 1978; Katz et al. 1981). Local There are not enough cases to provide comparisons of the two time periods or even to give a reliable survival curve for the 85-94 age-group for the more recent period.

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Aging and Cancer by Frederick F. Holmes M.D. (auth.)

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