By Nozomu Mori, Inhee Mook-Jung
This e-book brings jointly the main up to date details on fresh study result of prime laboratories on getting older technological know-how in East Asia, relatively in Japan, Korea, and Hong Kong. beginning with a entire evaluation of assorted hypotheses on organic mechanisms of getting older by way of Dr. Sataro Goto, every one bankruptcy covers vast facets of the newest findings in aging-related issues: centenarian reviews and genome research of progeria, metabolic biochemistry and neurobiology, sturdiness controls in yeast and nematodes, oxidative pressure and calorie restrict, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s ailments, with additional power healing methods to those age-related neurodegenerative illnesses. additionally incorporated, partly, is a precis and the results of a systematic dialogue discussion board known as the Asian getting older center for durability (AACL) that has been held every year alternating among Japan and Korea over the last decade. This ebook can function an invaluable source for locating acceptable collaborators within the parts it covers. the objective readership is made of graduate scholars and researchers at universities, scientific and/or life-science colleges, and biomedical and pharmaceutical institutes.
Why does getting older exist? How can we age? How is each one organism’s lifespan made up our minds? those are basic questions within the box. We will be nonetheless faraway from attaining a whole view of getting older mechanisms, yet this ebook, Aging Mechanisms, bargains a superb chance to get to grips with the main up to date growth within the biomedical study of getting older in Japan and Korea, the 2 best countries for human longevity.
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Extra info for Aging Mechanisms: Longevity, Metabolism, and Brain Aging
J Gerontol A Biol Sci Med Sci 57:B109–B114 Davies KJ (2001) Degradation of oxidized proteins by the 20S proteasome. Biochimie 83:301–310 de Duve C (1983) Lysosomes revisited. Eur J Biochem 137:391–397 Dolle´ ME, Snyder WK, Gossen JA, Lohman PH, Vijg J (2000) Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proc Natl Acad Sci U S A 97: 8403–8408 Drummond DA, Wilke CO (2009) The evolutionary consequences of erroneous protein synthesis. Nat Rev Genet 10:715–724 Fedorova M, Bollineni RC, Hoffmann R (2014) Protein carbonylation as a major hallmark of oxidative damage: update of analytical strategies.
2 Centenarian Studies: An Interdisciplinary Research on Healthy Longevity Fig. 2 Cognitive function of centenarians living in Tokyo. Cognitive function was assessed with clinical dementia rating and mini-mental state examination 35 % 50 40 30 20 10 0 Fig. 3 Medical history of centenarians living in Tokyo % 70 60 50 40 30 20 Men Women 10 0 About 97 % of the centenarians contracted chronic diseases (Takayama et al. 2007). 4 % in all individuals). 9 %, respectively. 0 %. The Ministry of Health, Labor and Welfare conducted a nation-wide survey of the prevalence of circulatory disease in Japanese adults (over 30 years old) in 2000.
More generally, amyloid diseases that impair the functions of different organs are also protein conformation diseases that increase with age. There are many other examples of protein misfolding and aggregation causing age-related diseases (Stefani 2004). While numerous cases, especially in neurodegenerative diseases, have been reported in which protein alterations produce age-related pathologies, it is not clear whether such changes also contribute to the functional decline of cells and tissues in physiological aging.
Aging Mechanisms: Longevity, Metabolism, and Brain Aging by Nozomu Mori, Inhee Mook-Jung